Ontology highlight
ABSTRACT:
SUBMITTER: Yamaguchi L
PROVIDER: S-EPMC5427934 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Yamaguchi Luna L Nishiyama Atsuya A Misaki Toshinori T Johmura Yoshikazu Y Ueda Jun J Arita Kyohei K Nagao Koji K Obuse Chikashi C Nakanishi Makoto M
Scientific reports 20170303 1
Uhrf1-dependent histone H3 ubiquitylation plays a crucial role in the maintenance of DNA methylation via the recruitment of the DNA methyltransferase Dnmt1 to DNA methylation sites. However, the involvement of deubiquitylating enzymes (DUBs) targeting ubiquitylated histone H3 in the maintenance of DNA methylation is largely unknown. With the use of Xenopus egg extracts, we demonstrate here that Usp7, a ubiquitin carboxyl-terminal hydrolase, forms a stable complex with Dnmt1 and is recruited to D ...[more]