Ontology highlight
ABSTRACT:
SUBMITTER: Schroeder MA
PROVIDER: S-EPMC5428459 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Schroeder Mark A MA Rettig Michael P MP Lopez Sandra S Christ Stephanie S Fiala Mark M Eades William W Mir Fazia A FA Shao Jin J McFarland Kyle K Trinkaus Kathryn K Shannon William W Deych Elena E Yu Jinsheng J Vij Ravi R Stockerl-Goldstein Keith K Cashen Amanda F AF Uy Geoffrey L GL Abboud Camille N CN Westervelt Peter P DiPersio John F JF
Blood 20170314 19
A single subcutaneous (SC) injection of plerixafor results in rapid mobilization of hematopoietic progenitors, but fails to mobilize 33% of normal allogeneic sibling donors in 1 apheresis. We hypothesized that changing the route of administration of plerixafor from SC to IV may overcome the low stem cell yields and allow collection in 1 day. A phase 1 trial followed by a phase 2 efficacy trial was conducted in allogeneic sibling donors. The optimal dose of IV plerixafor was determined to be 0.32 ...[more]