Gram-Negative Pneumonia Alters Large-Vein Cell-Adhesion Molecule Profile and Potentiates Experimental Stasis Venous Thrombosis.
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SUBMITTER: Obi AT
PROVIDER: S-EPMC5428541 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
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Gram-Negative Pneumonia Alters Large-Vein Cell-Adhesion Molecule Profile and Potentiates Experimental Stasis Venous Thrombosis.
Obi Andrea T AT Andraska Elizabeth E Kanthi Yogendra Y Luke Catherine E CE Elfline Megan M Madathilparambil Suresh S Siahaan Teruna J TJ Jaffer Farouc A FA Wakefield Thomas W TW Raghavendran Krishnan K Henke Peter K PK
Journal of vascular research 20161022 3-4
<h4>Background/aims</h4>Pneumonia is a significant risk factor for the development of venous thrombosis (VT). Cell-adhesion molecules (CAMs) are linked to the pathogenesis of both pneumonia and VT. We hypothesized that remote infection would confer a prothrombogenic milieu via systemic elevation of CAMs.<h4>Methods</h4>Lung injury was induced in wild-type (C57BL/6) mice by lung contusion or intratracheal inoculation with Klebsiella pneumoniae or saline controls. K. pneumoniae-treated mice and co ...[more]
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