Ontology highlight
ABSTRACT:
SUBMITTER: Gaiti F
PROVIDER: S-EPMC5429095 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Gaiti Federico F Jindrich Katia K Fernandez-Valverde Selene L SL Roper Kathrein E KE Degnan Bernard M BM Tanurdžić Miloš M
eLife 20170411
Combinatorial patterns of histone modifications regulate developmental and cell type-specific gene expression and underpin animal complexity, but it is unclear <i>when</i> this regulatory system evolved. By analysing histone modifications in a morphologically-simple, early branching animal, the sponge <i>Amphimedonqueenslandica</i>, we show that the regulatory landscape used by complex bilaterians was already in place at the dawn of animal multicellularity. This includes distal enhancers, repres ...[more]