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Higher dietary intakes of choline and betaine are associated with a lower risk of primary liver cancer: a case-control study.


ABSTRACT: The dietary intake of methyl donors is favorably associated with many diseases, but the findings regarding primary liver cancer (PLC) risk are limited. This study investigated the association between the intake of choline, betaine and methionine and PLC risk in adults. This 1:1 matched case-control study enrolled 644 hospital-based PLC patients and 644 community-based controls who were matched by sex and age, in Guangzhou, China. An interviewer-administered questionnaire and a food-frequency questionnaire were used to collect general information and dietary intake information. Conditional logistic regression showed a significantly inverse association between total choline and betaine intakes and PLC risk. The multivariable-adjusted odds ratios (ORs) and their 95% confidence intervals (CIs) for PLC for the top (vs. bottom) tertile were 0.34 (0.24-0.49; P -trend?-trend?=?0.011) for betaine. No significant association was observed between the intake of methionine and PLC risk (P?>?0.05). For individual choline compounds, higher consumptions of free choline, glycerophosphocholine, phosphocholine, phosphatidylcholine and sphingomyelin were associated with a lower PLC risk (all P-trend?

SUBMITTER: Zhou RF 

PROVIDER: S-EPMC5429604 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature

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Higher dietary intakes of choline and betaine are associated with a lower risk of primary liver cancer: a case-control study.

Zhou Rui-Fen RF   Chen Xiao-Lin XL   Zhou Zhong-Guo ZG   Zhang Yao-Jun YJ   Lan Qiu-Ye QY   Liao Gong-Cheng GC   Chen Yu-Ming YM   Zhu Hui-Lian HL  

Scientific reports 20170406 1


The dietary intake of methyl donors is favorably associated with many diseases, but the findings regarding primary liver cancer (PLC) risk are limited. This study investigated the association between the intake of choline, betaine and methionine and PLC risk in adults. This 1:1 matched case-control study enrolled 644 hospital-based PLC patients and 644 community-based controls who were matched by sex and age, in Guangzhou, China. An interviewer-administered questionnaire and a food-frequency que  ...[more]

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