Ontology highlight
ABSTRACT:
SUBMITTER: Xu X
PROVIDER: S-EPMC2775010 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
Xu Xinran X Gammon Marilie D MD Zeisel Steven H SH Bradshaw Patrick T PT Wetmur James G JG Teitelbaum Susan L SL Neugut Alfred I AI Santella Regina M RM Chen Jia J
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20090727 11
Choline and betaine provide methyl groups for one-carbon metabolism. Humans obtain these nutrients from a wide range of foods. Betaine can also be synthesized endogenously from its precursor, choline. Although animal studies have implied a causal relationship between choline deficiency and carcinogenesis, the role of these two nutrients in human carcinogenesis and tumor progression is not well understood. We investigated the associations of dietary intakes of choline and betaine and breast cance ...[more]