Ontology highlight
ABSTRACT:
SUBMITTER: Daly SM
PROVIDER: S-EPMC5429642 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Daly Seth M SM Joyner Jason A JA Triplett Kathleen D KD Elmore Bradley O BO Pokhrel Srijana S Frietze Kathryn M KM Peabody David S DS Chackerian Bryce B Hall Pamela R PR
Scientific reports 20170404 1
Staphylococcus aureus is the leading cause of skin and soft tissue infections (SSTIs) and mounting antibiotic resistance requires innovative treatment strategies. S. aureus uses secreted cyclic autoinducing peptides (AIPs) and the accessory gene regulator (agr) operon to coordinate expression of virulence factors required for invasive infection. Of the four agr alleles (agr types I-IV and corresponding AIPs1-4), agr type I isolates are most frequently associated with invasive infection. Cyclizat ...[more]