Ontology highlight
ABSTRACT:
SUBMITTER: Pan B
PROVIDER: S-EPMC5429650 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Pan Bin B Wang Xiangmin X Nishioka Chie C Honda Goichi G Yokoyama Akihito A Zeng Lingyu L Xu Kailin K Ikezoe Takayuki T
Scientific reports 20170406 1
Thrombomodulin (TM) stimulates angiogenesis and protects vascular endothelial cells (ECs) via its fifth epidermal growth factor-like region (TME5); however, the cell surface receptor that mediates the pro-survival signaling activated by TM has remained unknown. We applied pull-down assay followed by MALDI-TOF MS and western blot analysis, and identified G-protein coupled receptor 15 (GPR15) as a binding partner of TME5. TME5 rescued growth inhibition and apoptosis caused by calcineurin inhibitor ...[more]