Ontology highlight
ABSTRACT:
SUBMITTER: Wang Y
PROVIDER: S-EPMC5429731 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Wang Yu Y Harashima Shin-Ichi SI Liu Yanyan Y Usui Ryota R Inagaki Nobuya N
Scientific reports 20170410 1
Glucose-stimulated insulin secretion (GSIS) is essential in keeping blood glucose levels within normal range. GSIS is impaired in type 2 diabetes, and its recovery is crucial in treatment of the disease. We find here that sphingosine kinase 1-interacting protein (SKIP, also called Sphkap) is highly expressed in pancreatic β-cells but not in α-cells. Intraperitoneal glucose tolerance test showed that plasma glucose levels were decreased and insulin levels were increased in SKIP<sup>-/-</sup> mice ...[more]