Ontology highlight
ABSTRACT:
SUBMITTER: He Q
PROVIDER: S-EPMC5430443 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Scientific reports 20170419 1
The tandem Agenet domain (TAD) of fragile X mental retardation protein (FMRP) protein is considered to be a member of the methyl-lysine-binding Tudor domain "Royal family". Several groups have reported that the TAD binds with methylated histones and plays a role in DNA damage responses. FMRP is a RNA-binding protein predominantly resident in cytoplasm. Therefore, in this study, we identified DDX5, FUS, EWSR1 and LSM14A as TAD-interacting proteins sensitive to F32L and/or Y96L mutation by pull-do ...[more]