Ontology highlight
ABSTRACT:
SUBMITTER: Han Y
PROVIDER: S-EPMC5430779 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Han Yixing Y Ren Jianke J Lee Eunice E Xu Xiaoping X Yu Weishi W Muegge Kathrin K
Scientific reports 20170425 1
Epigenetic mechanisms are known to exert control over gene expression and determine cell fate. Genetic mutations in epigenetic regulators are responsible for several neurologic disorders. Mutations of the chromatin remodeling protein Lsh/HELLS can cause the human Immunodeficiency, Centromere instability and Facial anomalies (ICF) syndrome, which is associated with neurologic deficiencies. We report here a critical role for Lsh in murine neural development. Lsh depleted neural stem/progenitor cel ...[more]