Ontology highlight
ABSTRACT:
SUBMITTER: Yelshanskaya MV
PROVIDER: S-EPMC5430913 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Yelshanskaya Maria V MV Mesbahi-Vasey Samaneh S Kurnikova Maria G MG Sobolevsky Alexander I AI
Scientific reports 20170421 1
AMPA subtype ionotropic glutamate receptors mediate fast excitatory neurotransmission and are implicated in numerous neurological diseases. Ionic currents through AMPA receptor channels can be allosterically regulated via different sites on the receptor protein. We used site-directed mutagenesis and patch-clamp recordings to probe the ion channel extracellular collar, the binding region for noncompetitive allosteric inhibitors. We found position and substitution-dependent effects for introduced ...[more]