Picomolar Detection of Hydrogen Peroxide using Enzyme-free Inorganic Nanoparticle-based Sensor.

ABSTRACT: A philosophical shift has occurred in the field of biomedical sciences from treatment of late-stage disease symptoms to early detection and prevention. Ceria nanoparticles (CNPs) have been demonstrated to neutralize free radical chemical species associated with many life-threatening disease states such as cancers and neurodegenerative diseases by undergoing redox changes (Ce³⁺  ↔ Ce⁴⁺). Herein, we investigate the electrochemical response of multi-valent CNPs in presence of hydrogen peroxide and demonstrate an enzyme-free CNP-based biosensor capable of ultra-low (limit of quantitation: 0.1 pM) detection. Several preparations of CNPs with varying Ce³⁺:Ce⁴⁺ are produced and are analyzed by electrochemical methods. We find that an increasing magnitud

SUBMITTER: Neal CJ 

PROVIDER: S-EPMC5431009 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature