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Ethylenation of aldehydes to 3-propanal, propanol and propanoic acid derivatives.

ABSTRACT: Methodology has been developed for the synthesis of 3-propanaldehydes through a five-step process in 11-67% yield from aldehydes. Aldehydes were reacted with Meldrum's acid through a Knoevenagel condensation to give materials that upon reduction with sodium borohydride and subsequent hydrolysis decarboxylation generated the corresponding 3-propanoic acid derivatives. The -propanoic acid derivatives were reduced to give 3-propanol derivatives, which were readily oxidised to target 3-propanal derivatives.

SUBMITTER: Payne DT

PROVIDER: S-EPMC5431831 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature

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Ethylenation of aldehydes to 3-propanal, propanol and propanoic acid derivatives.

Payne Daniel T DT Zhao Yiming Y Fossey John S JS

Scientific reports 20170511 1

Methodology has been developed for the synthesis of 3-propanaldehydes through a five-step process in 11-67% yield from aldehydes. Aldehydes were reacted with Meldrum's acid through a Knoevenagel condensation to give materials that upon reduction with sodium borohydride and subsequent hydrolysis decarboxylation generated the corresponding 3-propanoic acid derivatives. The -propanoic acid derivatives were reduced to give 3-propanol derivatives, which were readily oxidised to target 3-propanal deri ...[more]

PMID: 28496208

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