Ontology highlight
ABSTRACT:
SUBMITTER: Payne DT
PROVIDER: S-EPMC5431831 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Scientific reports 20170511 1
Methodology has been developed for the synthesis of 3-propanaldehydes through a five-step process in 11-67% yield from aldehydes. Aldehydes were reacted with Meldrum's acid through a Knoevenagel condensation to give materials that upon reduction with sodium borohydride and subsequent hydrolysis decarboxylation generated the corresponding 3-propanoic acid derivatives. The -propanoic acid derivatives were reduced to give 3-propanol derivatives, which were readily oxidised to target 3-propanal deri ...[more]