Ontology highlight
ABSTRACT:
SUBMITTER: Bryce AH
PROVIDER: S-EPMC5432324 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Bryce Alan H AH Egan Jan B JB Borad Mitesh J MJ Stewart A Keith AK Nowakowski Grzegorz S GS Chanan-Khan Asher A Patnaik Mrinal M MM Ansell Stephen M SM Banck Michaela S MS Robinson Steven I SI Mansfield Aaron S AS Klee Eric W EW Oliver Gavin R GR McCormick Jennifer B JB Huneke Norine E NE Tagtow Colleen M CM Jenkins Robert B RB Rumilla Kandelaria M KM Kerr Sarah E SE Kocher Jean-Pierre A JA Beck Scott A SA Fernandez-Zapico Martin E ME Farrugia Gianrico G Lazaridis Konstantinos N KN McWilliams Robert R RR
Oncotarget 20170401 16
<h4>Background</h4>The ability to analyze the genomics of malignancies has opened up new possibilities for off-label targeted therapy in cancers that are refractory to standard therapy. At Mayo Clinic these efforts are organized through the Center for Individualized Medicine (CIM).<h4>Results</h4>Prior to GTB, datasets were analyzed and integrated by a team of bioinformaticians and cancer biologists. Therapeutically actionable mutations were identified in 65% (92/141) of the patients tested with ...[more]