Ontology highlight
ABSTRACT:
SUBMITTER: Pousada G
PROVIDER: S-EPMC5432510 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Pousada Guillermo G Lupo Vincenzo V Cástro-Sánchez Sheila S Álvarez-Satta María M Sánchez-Monteagudo Ana A Baloira Adolfo A Espinós Carmen C Valverde Diana D
Scientific reports 20170515 1
Pulmonary arterial hypertension is a progressive disease that causes the obstruction of precapillary pulmonary arteries and a sustained increase in pulmonary vascular resistance. The aim was to analyze functionally the variants found in the BMPR2 gene and to establish a genotype-phenotype correlation. mRNA expression studies were performed using pSPL3 vector, studies of subcellular localization were performed using pEGFP-N1 vector and luciferase assays were performed using pGL3-Basic vector. We ...[more]