Ontology highlight
ABSTRACT:
SUBMITTER: Cartland SP
PROVIDER: S-EPMC5432513 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Cartland Siân P SP Harith Hanis H HH Genner Scott W SW Dang Lei L Cogger Victoria C VC Vellozzi Melissa M Di Bartolo Belinda A BA Thomas Shane R SR Adams Leon A LA Kavurma Mary M MM
Scientific reports 20170515 1
Non-alcoholic fatty liver disease (NAFLD) incorporates steatosis, non-alcoholic steato-hepatitis (NASH) and liver cirrhosis, associating with diabetes and cardiovascular disease (CVD). TNF-related apoptosis-inducing ligand (TRAIL) is protective of CVD. We aimed to determine whether TRAIL protects against insulin resistance, NAFLD and vascular injury. Twelve-week high fat diet (HFD)-fed Trail <sup>-/-</sup> mice had increased plasma cholesterol, insulin and glucose compared to wildtype. Insulin t ...[more]