Ontology highlight
ABSTRACT:
SUBMITTER: Vorob'ev AY
PROVIDER: S-EPMC5433178 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Beilstein journal of organic chemistry 20170502
An efficient and operationally simple synthesis of 7-deuteropyrazolo[1,5-<i>a</i>]pyridine and 7-deutero-1,2,4-triazolo[1,5-<i>a</i>]pyridine derivatives using α-H/D exchange of 1-aminopyridinium cations in basic D<sub>2</sub>O followed by a 1,3-cycloaddition of acetylenes and nitriles is presented. A high regioselectivity and a high degree of deuterium incorporation were achieved. The procedure was applied for several 4-R-1-aminopyridinium cations (R = H, Me, OMe). ...[more]