Ontology highlight
ABSTRACT:
SUBMITTER: Inda C
PROVIDER: S-EPMC5434020 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Scientific reports 20170516 1
Corticotropin-releasing hormone receptor 1 (CRHR1) activates the atypical soluble adenylyl cyclase (sAC) in addition to transmembrane adenylyl cyclases (tmACs). Both cAMP sources were shown to be required for the phosphorylation of ERK1/2 triggered by activated G protein coupled receptor (GPCR) CRHR1 in neuronal and neuroendocrine contexts. Here, we show that activated CRHR1 promotes growth arrest and neurite elongation in neuronal hippocampal cells (HT22-CRHR1 cells). By characterising CRHR1 si ...[more]