Rapid evolution of the human mutation spectrum.
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ABSTRACT:
SUBMITTER: Harris K
PROVIDER: S-EPMC5435464 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Publications
Rapid evolution of the human mutation spectrum.
Harris Kelley K Pritchard Jonathan K JK
eLife 20170425
DNA is a remarkably precise medium for copying and storing biological information. This high fidelity results from the action of hundreds of genes involved in replication, proofreading, and damage repair. Evolutionary theory suggests that in such a system, selection has limited ability to remove genetic variants that change mutation rates by small amounts or in specific sequence contexts. Consistent with this, using SNV variation as a proxy for mutational input, we report here that mutational sp ...[more]
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