Ontology highlight
ABSTRACT:
SUBMITTER: Romee R
PROVIDER: S-EPMC5436500 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Romee Rizwan R Rosario Maximillian M Berrien-Elliott Melissa M MM Wagner Julia A JA Jewell Brea A BA Schappe Timothy T Leong Jeffrey W JW Abdel-Latif Sara S Schneider Stephanie E SE Willey Sarah S Neal Carly C CC Yu Liyang L Oh Stephen T ST Lee Yi-Shan YS Mulder Arend A Claas Frans F Cooper Megan A MA Fehniger Todd A TA
Science translational medicine 20160901 357
Natural killer (NK) cells are an emerging cellular immunotherapy for patients with acute myeloid leukemia (AML); however, the best approach to maximize NK cell antileukemia potential is unclear. Cytokine-induced memory-like NK cells differentiate after a brief preactivation with interleukin-12 (IL-12), IL-15, and IL-18 and exhibit enhanced responses to cytokine or activating receptor restimulation for weeks to months after preactivation. We hypothesized that memory-like NK cells exhibit enhanced ...[more]