Ontology highlight
ABSTRACT:
SUBMITTER: Shliaha PV
PROVIDER: S-EPMC5436587 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Shliaha Pavel V PV Baird Matthew A MA Nielsen Mogens M MM Gorshkov Vladimir V Bowman Andrew P AP Kaszycki Julia L JL Jensen Ole N ON Shvartsburg Alexandre A AA
Analytical chemistry 20170426 10
Histone proteins are subject to dynamic post-translational modifications (PTMs) that cooperatively modulate the chromatin structure and function. Nearly all functional PTMs are found on the N-terminal histone domains (tails) of ∼50 residues protruding from the nucleosome core. Using high-definition differential ion mobility spectrometry (FAIMS) with electron transfer dissociation, we demonstrate rapid baseline gas-phase separation and identification of tails involving monomethylation, trimethyla ...[more]