Ontology highlight
ABSTRACT:
SUBMITTER: Jie Z
PROVIDER: S-EPMC5436614 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Journal of immunology (Baltimore, Md. : 1950) 20170331 9
Although large amounts of vitamin A and its metabolite all-<i>trans</i> retinoic acid (RA) are stored in the liver, how RA regulates liver immune responses during viral infection remains unclear. In this study, we demonstrated that IL-22, mainly produced by hepatic γδ T cells, attenuated liver injury in adenovirus-infected mice. RA can promote γδ T cells to produce mTORC1-dependent IL-22 in the liver, but inhibits IFN-γ and IL-17. RA also affected the aptitude of T cell responses by modulating d ...[more]