Ontology highlight
ABSTRACT:
SUBMITTER: Andersen KR
PROVIDER: S-EPMC5437224 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
The Journal of biological chemistry 20170317 20
Metabolic products and environmental factors constantly damage DNA. To protect against these insults and maintain genome integrity, cells have evolved mechanisms to repair DNA lesions. One such mechanism involves Rad3, a master kinase coordinating the DNA damage response. Rad26 is a functional subunit of the Rad3-Rad26 complex and is responsible for bringing the kinase to sites of DNA damage. Here, I present the crystal structure of Rad26 and identify the elements important for recruiting Rad3. ...[more]