2-Hydroxypropyl-beta-cyclodextrin (HP?CD) reduces age-related lipofuscin accumulation through a cholesterol-associated pathway.
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ABSTRACT:
SUBMITTER: Gaspar J
PROVIDER: S-EPMC5438378 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
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2-Hydroxypropyl-beta-cyclodextrin (HPβCD) reduces age-related lipofuscin accumulation through a cholesterol-associated pathway.
Gaspar Jason J Mathieu Jacques J Alvarez Pedro P
Scientific reports 20170519 1
Oxidative stress causes significant increases in both cholesterol uptake and intracellular accumulation of the aging biomarker lipofuscin. Here we show that HPβCD addition mitigates these adverse effects in human fibroblasts by significantly reducing LDLr and SREBP1 gene expression. In the absence of oxidative stress, HPβCD addition induces a paradoxical response, increasing cholesterol accumulation (but not lipofuscin) via upregulation of cholesterol biosynthesis. These two distinct, but opposi ...[more]
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