Ontology highlight
ABSTRACT:
SUBMITTER: Sun ZJ
PROVIDER: S-EPMC5438713 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Sun Zu-Jun ZJ Wu Yi Y Hou Wei-Hua WH Wang Yu-Xiong YX Yuan Qing-Yun QY Wang Hui-Jie HJ Yu Min M
Oncotarget 20170401 17
The bispecific antibody is a novel antibody, which can target two different antigens and mediate specific killing effects by selectively redirecting effector cells to the target cells. Here, we designed and synthesized a bispecific antibody (BsAb) that can bind cellular-mesenchymal to epithelial transition factor (c-MET, overexpressed in several human solid tumor), and programmed death-1 (PD-1, involved in cancer cell immune evasion) with high affinity and specificity. We found that BsAb can ind ...[more]