Ontology highlight
ABSTRACT:
SUBMITTER: Yoon A
PROVIDER: S-EPMC7175222 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Yoon Aerin A Lee Shinai S Lee Sua S Lim Sojung S Park Yong-Yea YY Song Eunjung E Kim Dong-Sik DS Kim Kisu K Lim Yangmi Y
Biomolecules 20200304 3
As mesothelin is overexpressed in various types of cancer, it is an attractive target for therapeutic antibodies. T-cell bispecific antibodies bind to target cells and engage T cells via binding to CD3, resulting in target cell killing by T-cell activation. However, the affinity of the CD3-binding arm may influence CD3-mediated plasma clearance or antibody trapping in T-cell-containing tissues. This may then affect the biodistribution of bispecific antibodies. In this study, we used scFab and kn ...[more]