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Pertussis Antibody Transfer to Preterm Neonates After Second- Versus Third-Trimester Maternal Immunization.

ABSTRACT: Preterm infants are most vulnerable to pertussis. Whether they might benefit from maternal immunization is unknown. Extending our previous results in term neonates, this observational study demonstrates that second- rather than third-trimester maternal vaccination results in higher birth anti-pertussis toxin titers in preterm neonates.

SUBMITTER: Eberhardt CS 

PROVIDER: S-EPMC5439344 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature

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Pertussis Antibody Transfer to Preterm Neonates After Second- Versus Third-Trimester Maternal Immunization.

Eberhardt Christiane S CS   Blanchard-Rohner Geraldine G   Lemaître Barbara B   Combescure Christophe C   Othenin-Girard Véronique V   Chilin Antonina A   Petre Jean J   Martinez de Tejada Begoña B   Siegrist Claire-Anne CA  

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20170401 8

Preterm infants are most vulnerable to pertussis. Whether they might benefit from maternal immunization is unknown. Extending our previous results in term neonates, this observational study demonstrates that second- rather than third-trimester maternal vaccination results in higher birth anti-pertussis toxin titers in preterm neonates. ...[more]

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