Ontology highlight
ABSTRACT:
SUBMITTER: Topisirovic I
PROVIDER: S-EPMC544005 | biostudies-literature | 2005 Feb
REPOSITORIES: biostudies-literature
Topisirovic Ivan I Kentsis Alex A Perez Jacqueline M JM Guzman Monica L ML Jordan Craig T CT Borden Katherine L B KL
Molecular and cellular biology 20050201 3
The eukaryotic translation initiation factor 4E (eIF4E) alters gene expression on multiple levels. In the cytoplasm, eIF4E acts in the rate-limiting step of translation initiation. In the nucleus, eIF4E facilitates nuclear export of a subset of mRNAs. Both of these functions contribute to eIF4E's ability to oncogenically transform cells. We report here that the homeodomain protein, HOXA9, is a positive regulator of eIF4E. HOXA9 stimulates eIF4E-dependent export of cyclin D1 and ornithine decarbo ...[more]