Ontology highlight
ABSTRACT:
SUBMITTER: Menzies RI
PROVIDER: S-EPMC5440600 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Menzies Robert I RI Booth John W R JWR Mullins John J JJ Bailey Matthew A MA Tam Frederick W K FWK Norman Jill T JT Unwin Robert J RJ
EBioMedicine 20170420
Diabetes is a leading cause of renal disease. Glomerular mesangial expansion and fibrosis are hallmarks of diabetic nephropathy and this is thought to be promoted by infiltration of circulating macrophages. Monocyte chemoattractant protein-1 (MCP-1) has been shown to attract macrophages in kidney diseases. P2X7 receptors (P2X7R) are highly expressed on macrophages and are essential components of pro-inflammatory signaling in multiple tissues. Here we show that in diabetic patients, renal P2X7R e ...[more]