IL-24 Promotes Pseudomonas aeruginosa Keratitis in C57BL/6 Mouse Corneas.
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ABSTRACT:
SUBMITTER: Ross BX
PROVIDER: S-EPMC5440843 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
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IL-24 Promotes <i>Pseudomonas aeruginosa</i> Keratitis in C57BL/6 Mouse Corneas.
Ross Bing X BX Gao Nan N Cui Xinhan X Standiford Theodore J TJ Xu Jianjiang J Yu Fu-Shin X FX
Journal of immunology (Baltimore, Md. : 1950) 20170322 9
The aim of this study was to elucidate the expression and functions of IL-24 in C57BL/6 mouse corneas in response to <i>Pseudomonas aeruginosa</i> infection. Among IL-20R cytokines, only IL-24 was induced at both mRNA and protein levels by infection at early time points. The upregulation of IL-24 was dampened by flagellin pretreatment, which protects the corneas from microbial infection. Time course studies revealed bimodal early and later peaks of IL-24 expression, a pattern shared with suppres ...[more]
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