Ontology highlight
ABSTRACT:
SUBMITTER: Travers SA
PROVIDER: S-EPMC544114 | biostudies-literature | 2005 Feb
REPOSITORIES: biostudies-literature
Journal of virology 20050201 3
Recent studies have demonstrated the emergence of human immunodeficiency virus type 1 (HIV-1) subtypes with various levels of fitness. Using heterogeneous maximum-likelihood models of adaptive evolution implemented in the PAML software package, with env sequences representing each HIV-1 group M subtype, we examined the various intersubtype selective pressures operating across the env gene. We found heterogeneity of evolutionary mechanisms between the different subtypes with a category of amino a ...[more]