Ontology highlight
ABSTRACT:
SUBMITTER: Liu Y
PROVIDER: S-EPMC5441742 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Liu Yongfeng Y Peng Junjie J Sun Tongyu T Li Ni N Zhang Le L Ren Jiale J Yuan Huairui H Kan Shan S Pan Qiang Q Li Xiang X Ding Yufeng Y Jiang Min M Cong Xiaoji X Tan Minjia M Ma Yushui Y Fu Da D Cai Sanjun S Xiao Yichuan Y Wang Xiaoming X Qin Jun J
Proceedings of the National Academy of Sciences of the United States of America 20170424 19
Epithelial barrier disruption is a major cause of inflammatory bowel disease (IBD); however, the mechanism through which epigenetic regulation modulates intestinal epithelial integrity remains largely undefined. Here we show that EZH2, the catalytic subunit of polycomb repressive complex (PRC2), is indispensable for maintaining epithelial cell barrier integrity and homeostasis under inflammatory conditions. In accordance with reduced EZH2 expression in patients, the inactivation of EZH2 in IECs ...[more]