Ontology highlight
ABSTRACT:
SUBMITTER: O'Flanagan CH
PROVIDER: S-EPMC5442682 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
O'Flanagan Ciara H CH Smith Laura A LA McDonell Shannon B SB Hursting Stephen D SD
BMC medicine 20170524 1
Calorie restriction (CR) extends lifespan and has been shown to reduce age-related diseases including cancer, diabetes, and cardiovascular and neurodegenerative diseases in experimental models. Recent translational studies have tested the potential of CR or CR mimetics as adjuvant therapies to enhance the efficacy of chemotherapy, radiation therapy, and novel immunotherapies. Chronic CR is challenging to employ in cancer patients, and therefore intermittent fasting, CR mimetic drugs, or alternat ...[more]