Ontology highlight
ABSTRACT:
SUBMITTER: Heggelund JE
PROVIDER: S-EPMC5443773 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Heggelund Julie Elisabeth JE Mackenzie Alasdair A Martinsen Tobias T Heim Joel Benjamin JB Cheshev Pavel P Bernardi Anna A Krengel Ute U
Scientific reports 20170524 1
Cholera is a life-threatening disease in many countries, and new drugs are clearly needed. C-glycosidic antagonists may serve such a purpose. Here we report atomic-resolution crystal structures of three such compounds in complexes with the cholera toxin. The structures give unprecedented atomic details of the molecular interactions and show how the inhibitors efficiently block the GM1 binding site. These molecules are well suited for development into low-cost prophylactic drugs, due to their rel ...[more]