Dataset Information
Th1/Th2 Balance and Th17/Treg-Mediated Immunity in relation to Murine Resistance to Dextran Sulfate-Induced Colitis.
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ABSTRACT: Background
The role of the Th17/Treg balance in the development of experimental colitis remains poorly understood.Methods
We exploited the differential response of BALB/c mice and C57BL/6 mice towards drinking water mediated by dextran sulfate sodium (DSS) challenge.Results
DSS-resistant BALB/c mice were characterized by low levels of IFN-? and TNF-? but high levels of IL-4, IL-6, IL-10, IL-17A, IL-17F, and colon lamina propria and mesenteric lymph node (MLN) CD4+CD25+FoxP3+ T cells when compared to C57BL/6 mice. Collectively, these data indicate the propensity of BALB/c mice towards a Th2/Th17/Treg-polarized immunity protecting these animals against DSS challenge, whereas Th1-polarization of C57BL/6 mice confers sensitivity to DSS-induced colitis.Conclusions
The intrinsic congenital capacity of mouse strains with respect to T cell proliferation determines sensitivity to experimental colitis.
SUBMITTER: Yang F
PROVIDER: S-EPMC5444015 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Publications
Th1/Th2 Balance and Th17/Treg-Mediated Immunity in relation to Murine Resistance to Dextran Sulfate-Induced Colitis.
Journal of immunology research 20170511
<h4>Background</h4>The role of the Th17/Treg balance in the development of experimental colitis remains poorly understood.<h4>Methods</h4>We exploited the differential response of BALB/c mice and C57BL/6 mice towards drinking water mediated by dextran sulfate sodium (DSS) challenge.<h4>Results</h4>DSS-resistant BALB/c mice were characterized by low levels of IFN-<i>γ</i> and TNF-<i>α</i> but high levels of IL-4, IL-6, IL-10, IL-17A, IL-17F, and colon lamina propria and mesenteric lymph node (MLN ...[more]