Ontology highlight
ABSTRACT:
SUBMITTER: Jun SY
PROVIDER: S-EPMC5444177 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Jun Soo Youn SY Jang In Jin IJ Yoon Seonghae S Jang Kyungho K Yu Kyung-Sang KS Cho Joo Youn JY Seong Moon-Woo MW Jung Gi Mo GM Yoon Seong Jun SJ Kang Sang Hyeon SH
Antimicrobial agents and chemotherapy 20170524 6
This study was a phase 1, single-center, randomized, double-blind, placebo-controlled, single-dosing, and dose-escalating study of intravenous SAL200. It is a new candidate drug for the treatment of antibiotic-resistant staphylococcal infections based on a recombinant form of the phage endolysin SAL-1. The study evaluated the pharmacokinetics, pharmacodynamics, and tolerance among healthy male volunteers after the intravenous infusion of single ascending doses of SAL200 (0.1, 0.3, 1, 3, and 10 m ...[more]