A benchmark of gene expression tissue-specificity metrics.
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ABSTRACT:
SUBMITTER: Kryuchkova-Mostacci N
PROVIDER: S-EPMC5444245 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Publications
A benchmark of gene expression tissue-specificity metrics.
Kryuchkova-Mostacci Nadezda N Robinson-Rechavi Marc M
Briefings in bioinformatics 20170301 2
One of the major properties of genes is their expression pattern. Notably, genes are often classified as tissue specific or housekeeping. This property is of interest to molecular evolution as an explanatory factor of, e.g. evolutionary rate, as well as a functional feature which may in itself evolve. While many different methods of measuring tissue specificity have been proposed and used for such studies, there has been no comparison or benchmarking of these methods to our knowledge, and little ...[more]
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