Ontology highlight
ABSTRACT:
SUBMITTER: Bornigen D
PROVIDER: S-EPMC3794609 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Börnigen Daniela D Pers Tune H TH Thorrez Lieven L Huttenhower Curtis C Moreau Yves Y Brunak Søren S
Nucleic acids research 20130805 18
Disease-causing variants in human genes usually lead to phenotypes specific to only a few tissues. Here, we present a method for predicting tissue specificity based on quantitative deregulation of protein complexes. The underlying assumption is that the degree of coordinated expression among proteins in a complex within a given tissue may pinpoint tissues that will be affected by a mutation in the complex and coordinated expression may reveal the complex to be active in the tissue. We identified ...[more]