Ontology highlight
ABSTRACT:
SUBMITTER: Thangavel C
PROVIDER: S-EPMC5700768 | biostudies-literature | 2017 Feb
REPOSITORIES: biostudies-literature
Cancer research 20161206 4
RB loss occurs commonly in neoplasia but its contributions to advanced cancer have not been assessed directly. Here we show that RB loss in multiple murine models of cancer produces a prometastatic phenotype. Gene expression analyses showed that regulation of the cell motility receptor RHAMM by the RB/E2F pathway was critical for epithelial-mesenchymal transition, motility, and invasion by cancer cells. Genetic modulation or pharmacologic inhibition of RHAMM activity was sufficient and necessary ...[more]