Ontology highlight
ABSTRACT:
SUBMITTER: Miao L
PROVIDER: S-EPMC5444767 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Oncotarget 20170501 18
Breast cancer 1 (BRCA1) gene makes great contributions to the repair of DNA. The association between BRCA1 P871L polymorphism and cancer risk has been investigated in a growing number of studies, but the conclusions are not conclusive. To obtain a comprehensive conclusion, we performed a meta-analysis of 24 studies with 13762 cases and 22388 controls. The pooled results indicated that BRCA1 gene P871L variant decreased risk of overall cancer (homozygous model: odds ratio (OR) = 0.89, 95%confiden ...[more]