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Association between BRCA1 polymorphisms rs799917 and rs1799966 and breast cancer risk: a meta-analysis.

ABSTRACT: BACKGROUND:Several studies have reported correlations between BRCA1 polymorphisms rs799917 and rs1799966 with the risk of breast cancer (BC). However, this relationship remains controversial. METHODS:We conducted a meta-analysis of seven studies to assess the associations between BRCA1 rs799917 and rs1799966 and BC risk, with the aim of more accurately determining the potential correlation. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated to evaluate the correlation of rs799917 and rs1799966 with BC risk. RESULTS:There was no overall correlation between BRCA1 rs799917 and BC risk (TT vs CC: OR?=?0.87, 95% CI?=?0.66-1.16; CT vs CC: OR?=?1.02, 95% CI?=?0.89-1.15; dominant model: OR?=?0.99, 95% CI?=?0.88-1.11; recessive model: OR?=?0.87, 95% CI?=?0.65-1.16). Subgroup analysis by ethnicity also revealed no significant correlation between rs799917 and BC risk in either Asians or Caucasians. There was also no significant association between BRCA1 rs1799966 and BC risk (GG vs AA: OR?=?0.70, 95% CI?=?0.33-1.47; AG vs AA: OR?=?0.68, 95% CI?=?0.35-1.30; dominant model: OR?=?0.76, 95% CI?=?0.49-1.06; recessive model: OR?=?0.82, 95% CI?=?0.49-1.36). CONCLUSION:BRCA1polymorphisms rs799917 and rs1799966 were not significantly associated with BC risk in this meta-analysis.

SUBMITTER: Yang M

PROVIDER: S-EPMC6460623 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature

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Association between BRCA1 polymorphisms rs799917 and rs1799966 and breast cancer risk: a meta-analysis.

Yang Meiming M Du Xiaoli X Zhang Feng F Yuan Shifang S

The Journal of international medical research 20190305 4

<h4>Background</h4>Several studies have reported correlations between BRCA1 polymorphisms rs799917 and rs1799966 with the risk of breast cancer (BC). However, this relationship remains controversial.<h4>Methods</h4>We conducted a meta-analysis of seven studies to assess the associations between BRCA1 rs799917 and rs1799966 and BC risk, with the aim of more accurately determining the potential correlation. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated to evaluate the correla ...[more]

PMID: 30832521

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Project description:BackgroundThe base excision repair (BER) pathway removes DNA damage caused by ionizing radiation, reactive oxidative species and methylating agents. OGG1 and APE1 are two important genes in the BER pathway. Many epidemiological studies have evaluated the association between polymorphisms in the two BER genes (OGG1 Ser326Cys and APE1 Asp148Glu) and breast cancer risk. However, the results are inconsistent.MethodsWe searched the electronic databases including PubMed, Embase and Cochrane library for all eligible studies for the period up to February 2014. Data were extracted by two independent authors and pooled odds ratios (ORs) with corresponding 95% confidence intervals (CIs) were used to assess the strength of the association.ResultsA total of 17 studies including 9,040 cases and 10,042 controls were available for OGG1 Ser326Cys polymorphism and 7 studies containing 2,979 cases and 3,111 controls were included for APE1 Asp148Glu polymorphism. With respect to OGG1 Ser326Cys polymorphism, we did not find a significant association with breast cancer risk when all eligible studies were pooled into the meta-analysis. However, in subgroup analyses by ethnicity and menopausal status, statistical significant increased breast cancer risk was found in Asian populations (Cys/Cys vs. Ser/Ser: OR=1.157, 95% CI 1.013-1.321, P=0.011; Cys/Cys vs. Ser/Cys+Ser/Ser: OR=1.113, 95% CI 1.009-1.227, P=0.014) and postmenopausal patients (Cys/Cys vs. Ser/Cys+Ser/Ser: OR=1.162, 95% CI 1.003-1.346, P=0.024). In subgroup analysis according to quality score, source of control, and HWE in controls, no any significant association was detected. With respect to APE1 Asp148Glu polymorphism, no significant association with breast cancer risk was demonstrated in the overall and stratified analyses.ConclusionsThe present meta-analysis suggests that the OGG1 Ser326Cys polymorphism may be a risk factor for breast cancer in Asians and postmenopausal patients. Further large and well-designed studies are needed to confirm this association.Virtual slidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1156934297124915.

Dataset Information

Association between BRCA1 polymorphisms rs799917 and rs1799966 and breast cancer risk: a meta-analysis.

Publications

Association between BRCA1 polymorphisms rs799917 and rs1799966 and breast cancer risk: a meta-analysis.

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