Ontology highlight
ABSTRACT:
SUBMITTER: Chai MH
PROVIDER: S-EPMC5446427 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Chai Melissa H MH Weiland Florian F Harvey Richard M RM Hoffmann Peter P Ogunniyi Abiodun D AD Paton James C JC
Scientific reports 20170526 1
Streptococcus pneumoniae (the pneumococcus) is a human pathogen, accounting for massive global morbidity and mortality. Although asymptomatic colonization of the nasopharynx almost invariably precedes disease, the critical determinants enabling pneumococcal progression from this niche to cause invasive disease are poorly understood. One mechanism proposed to be central to this transition involves opacity phase variation, whereby pneumococci harvested from the nasopharynx are typically transparen ...[more]