Ontology highlight
ABSTRACT:
SUBMITTER: Goodwani S
PROVIDER: S-EPMC5446930 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Goodwani Sunil S Saternos Hannah H Alasmari Fawaz F Sari Youssef Y
Neuroscience and biobehavioral reviews 20170224
Emerging evidence indicates that dysfunctional glutamate neurotransmission is critical in the initiation and development of alcohol and drug dependence. Alcohol consumption induced downregulation of glutamate transporter 1 (GLT-1) as reported in previous studies from our laboratory. Glutamate is the major excitatory neurotransmitter in the brain, which acts via interactions with several glutamate receptors. Alcohol consumption interferes with the glutamatergic signal transmission by altering the ...[more]