Ontology highlight
ABSTRACT:
SUBMITTER: Bao J
PROVIDER: S-EPMC7220378 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
eLife 20200513
Type 1 metabotropic glutamate receptors (mGluR1s) are key elements in neuronal signaling. While their function is well documented in slices, requirements for their activation in vivo are poorly understood. We examine this question in adult mice in vivo using 2-photon imaging of cerebellar molecular layer interneurons (MLIs) expressing GCaMP. In anesthetized mice, parallel fiber activation evokes beam-like Ca<sub>i</sub> rises in postsynaptic MLIs which depend on co-activation of mGluR1s and iono ...[more]