Ontology highlight
ABSTRACT:
SUBMITTER: Hui KL
PROVIDER: S-EPMC5448208 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Hui King Lam KL Upadhyaya Arpita A
Proceedings of the National Academy of Sciences of the United States of America 20170510 21
T-cell receptor (TCR) triggering and subsequent T-cell activation are essential for the adaptive immune response. Recently, multiple lines of evidence have shown that force transduction across the TCR complex is involved during TCR triggering, and that the T cell might use its force-generation machinery to probe the mechanical properties of the opposing antigen-presenting cell, giving rise to different signaling and physiological responses. Mechanistically, actin polymerization and turnover have ...[more]