Ontology highlight
ABSTRACT:
SUBMITTER: Haibara H
PROVIDER: S-EPMC5448606 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Haibara Hirotaka H Yamazaki Ryuta R Nishiyama Yukiko Y Ono Masahiro M Kobayashi Tsuneyuki T Hokkyo-Itagaki Atsuko A Nishisaka Fukiko F Nishiyama Hiroyuki H Kurita Akinobu A Matsuzaki Takeshi T Izumi Hiroto H Kohno Kimitoshi K
Cancer science 20170424 5
Zinc-finger protein 143 (ZNF143) is a transcription factor that is involved in anticancer drug resistance and cancer cell survival. In the present study, we identified a novel small molecule N-(5-bromo-2-methoxyphenyl)-3-(pyridine-3-yl) propiolamide (YPC-21661) that inhibited ZNF143 promoter activity and down-regulated the expression of the ZNF143-regulated genes, RAD51, PLK1, and Survivin, by inhibiting the binding of ZNF143 to DNA. In addition, YPC-21661 was cytotoxic and induced apoptosis in ...[more]