Ontology highlight
ABSTRACT:
SUBMITTER: Bullock TN
PROVIDER: S-EPMC5449212 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Current opinion in immunology 20170317
The capacity of the immune system to recognize and respond to tumors has been appreciated for over 100 years. However, clinical success has largely depended on the elucidation of the positive and negative regulators of effector cells after their activation via the antigen cell receptor. On the one hand, effector cells upregulate checkpoint molecules that are thought to play a role in limiting immunopathology. On the other, second and third waves of costimulation are often required to promote the ...[more]