Ontology highlight
ABSTRACT:
SUBMITTER: Labrijn AF
PROVIDER: S-EPMC5449386 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Labrijn Aran F AF Meesters Joyce I JI Bunce Matthew M Armstrong Anthony A AA Somani Sandeep S Nesspor Tom C TC Chiu Mark L ML Altintaş Işil I Verploegen Sandra S Schuurman Janine J Parren Paul W H I PWHI
Scientific reports 20170530 1
Therapeutic concepts exploiting tumor-specific antibodies are often established in pre-clinical xenograft models using immuno-deficient mice. More complex therapeutic paradigms, however, warrant the use of immuno-competent mice, that more accurately capture the relevant biology that is being exploited. These models require the use of (surrogate) mouse or rat antibodies to enable optimal interactions with murine effector molecules. Immunogenicity is furthermore decreased, allowing longer-term tre ...[more]