Ontology highlight
ABSTRACT:
SUBMITTER: Wang F
PROVIDER: S-EPMC6927765 | biostudies-literature | 2020 Jan-Dec
REPOSITORIES: biostudies-literature
Wang Feng F Tsai Jordan C JC Davis Jonathan H JH Chau Bryant B Dong Jia J West Sean M SM Hogan Jason M JM Wheeler Matthew L ML Bee Christine C Morishige Winse W Cayton Thomas T David-Brown Donata D Zhang Chengyue C Kozhich Alexander A Sproul Tim T Dollinger Gavin G Rajpal Arvind A Strop Pavel P
mAbs 20200101 1
The development of antibody therapeutics relies on animal models that accurately recapitulate disease biology. Syngeneic mouse models are increasingly used with new molecules to capture the biology of complex cancers and disease states, and to provide insight into the role of the immune system. The establishment of syngeneic mouse models requires the ability to generate surrogate mouse counterparts to antibodies designed for humans. In the field of bispecific antibodies, there remains a dearth o ...[more]